GluR2 Antibody (1059613) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 1059613
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

GluR2 Antibody (1059613) [Alexa Fluor® 594] Summary

• Immunogen: Human GluR2/GRIA2 containing peptide
  Accession # P42262
• Specificity: Detects human GluR2/GRIA2 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GluR2 Antibody (1059613) [Alexa Fluor® 594]

• AMPA 2
• AMPA2
• GluA2
• GluR2
• GLURB
• GluR-K2
• glutamate receptor, ionotropic, AMPA 2
• GRIA2
• HBGR2

Background

GluR2 is a receptor for glutamate.  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain. The subunit encoded by this gene (GRIA2) is subject to RNA editing which renders the receptor it becomes part of impermeable to calcium ions.  This editing occurs at the Q/R site at a frequency of 100% of GluR2 transcripts in the brain.  The main function of this editing is regulation of electrophysiology of the receptor channel.  Defective editing of this channel has been linked to several conditions such as ALS, Epilepsy and some human brain tumors.  GRIA2 is a diagnostic immunochemical marker for solitary fibrous tumor which distinguishes it from most mimics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.