GluR2 Antibody (1059613) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 1059613
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

GluR2 Antibody (1059613) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human GluR2/GRIA2 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GluR2 Antibody (1059613) [Alexa Fluor™ Plus 488]

• AMPA 2
• AMPA2
• GluA2
• GluR2
• GLURB
• GluR-K2
• glutamate receptor, ionotropic, AMPA 2
• GRIA2
• HBGR2

Background

GluR2 is a receptor for glutamate.  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain. The subunit encoded by this gene (GRIA2) is subject to RNA editing which renders the receptor it becomes part of impermeable to calcium ions.  This editing occurs at the Q/R site at a frequency of 100% of GluR2 transcripts in the brain.  The main function of this editing is regulation of electrophysiology of the receptor channel.  Defective editing of this channel has been linked to several conditions such as ALS, Epilepsy and some human brain tumors.  GRIA2 is a diagnostic immunochemical marker for solitary fibrous tumor which distinguishes it from most mimics.

1. Entrez Gene:  GRIA glutamate receptor, ionotropic, AMPA 2.
2. Seeburg PH, Single F, Kuner T, Higuchi M, Sprengel R. "Genetic Manipulation of Key Determinants of Ion Flow in Glutamate Receptor Channels in the Mouse". Brain Res.  2001 Jul; 907(1-2):233. 
3. Cleveland DW, Rothstein JD. "From Charcot to Lou Gehrig:  Deciphering Selective Motor Neuron Death in ALS". Nat. Rev. Neurosci. 2001 Nov; 2(11):806.
4. Maas S, Patt S, Schrey M, Rich A. "Underediting of Glutamate Receptor GluR-B mRNA in Malignant Gliomas". Proc. Natl. Acad. Sci. U.S.A. 2001 Dec; 98(25):14687. 
5. Vivero M, Doyle L.A, Fletcher C.D., Mertens F, Hornick J.L. "GRIA2 is a Novel Diagnostic Marker for Solitary Fibrous Tumour Identified through Gene Expression Profiling". Histopathology. 2014. 65(1):71.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.