Glucokinase/GCK Antibody

Images

 
Western Blot: Glucokinase/GCK Antibody [H00002645-D01P] - Analysis of GCK expression in mouse liver.
Immunocytochemistry/ Immunofluorescence: Glucokinase/GCK Antibody [H00002645-D01P] - Analysis of antibody to GCK on HeLa cell. Antibody concentration 10 ug/ml.
Western Blot: Glucokinase/GCK Antibody [H00002645-D01P] - Analysis of GCK expression in PC-12.
Western Blot: Glucokinase/GCK Antibody [H00002645-D01P] - Analysis of GCK expression in human spleen.
Western Blot: Glucokinase/GCK Antibody [H00002645-D01P] - Analysis of GCK expression in transfected 293T cell line by GCK polyclonal antibody.Lane 1: GCK transfected lysate(52.20 KDa).Lane 2: Non-transfected lysate.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit

Order Details

Glucokinase/GCK Antibody Summary

Immunogen
GCK (AAH01890.1, 1 a.a. ~ 465 a.a) full-length human protein.MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT
Specificity
GCK - glucokinase (hexokinase 4, maturity onset diabetes of the young 2),
Clonality
Polyclonal
Host
Rabbit
Gene
GCK
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA
  • Immunocytochemistry/Immunofluorescence
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Reactivity Notes

Human, Mouse, Rat

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Glucokinase/GCK Antibody

  • EC 2.7.1
  • EC 2.7.1.2
  • FGQTL3
  • GCK
  • GK
  • GLK
  • glucokinase (hexokinase 4)
  • Glucokinase/GCK
  • Hexokinase-4
  • Hexokinase-D
  • HHF3
  • HK4
  • HK4pancreatic isozyme
  • HKIV
  • HXKP
  • LGLK
  • maturity onset diabetes of the young 2
  • MODY2

Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Glucokinase/GCK Antibody (H00002645-D01P) (0)

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Secondary Antibodies

 

Isotype Controls

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Diseases for Glucokinase/GCK Antibody (H00002645-D01P)

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol GCK
Entrez
Uniprot

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