Glucokinase/GCK Products

Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Bioinformatics

Entrez	2645 Human
Uniprot	AAH01890 Human
Product By Gene ID	2645
Alternate Names	EC 2.7.1 EC 2.7.1.2 FGQTL3 GCK GK GLK glucokinase (hexokinase 4) Glucokinase Hexokinase-4 Hexokinase-D HHF3 HK4 HK4pancreatic isozyme HKIV HXKP LGLK maturity onset diabetes of the young 2 MODY2

Research Areas for Glucokinase/GCK

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Protein Kinase