GLI-2 Antibody (442211) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 442211
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

GLI-2 Antibody (442211) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human GLI-2
  Met1-Gly91
  Accession # P10070
• Specificity: Detects human GLI-2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GLI-2 Antibody (442211) [Alexa Fluor® 700]

• GLI family zinc finger 2
• GLI2
• GLI-2
• GLI-Kruppel family member GLI2
• glioma-associated oncogene family zinc finger 2
• HPE9tax helper protein 1
• oncogene GLI2
• tax helper protein 2
• Tax helper protein
• tax-responsive element-2 holding protein
• tax-responsive element-25-bp sequence binding protein
• THP
• THP1
• THP2
• zinc finger protein GLI2

Background

GLI-2 is a 166 kDa biopotential transcription regulator of the hedgehog signaling pathway. It contains 5 conserved tandem C2H2 zinc finger domains that are flanked by a repression domain at the N-terminal region and an activation domain in the C-terminal region. At least four isoforms that differ in their N- or C-terminal regions have been described. Transcriptional activity of GLI-2 is regulated by proteolytic processing and degradation. Within the region used as immunogen, human and mouse GLI-2 share 88% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.