Home » GFR alpha-4/GDNF R alpha-4/Persephin receptor » GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibodies » GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (RM0244-1M21) [HRP]

GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (RM0244-1M21) [HRP]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-12415H
    • Availability
      Product Discontinued

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GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (RM0244-1M21) [HRP] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Mouse
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
GFRA4
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (RM0244-1M21) [HRP]

  • GDNF family receptor alpha 4
  • GDNF family receptor alpha-4
  • GDNF R alpha-4
  • GDNF receptor alpha-4
  • GDNFR-alpha-4
  • GFR alpha4
  • GFR alpha-4
  • GFR receptor alpha 4
  • GFRA4
  • GFRa-4
  • GFR-alpha-4
  • Persephin receptor

Background

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GFRA4
Uniprot