Gemin 5 Antibody

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Independent Antibodies: Western Blot: Gemin 5 Antibody [NB100-61049] - Detection of Human Gemin5 on HeLa whole cell lysate using NB100-61049. Gemin5 was also immunoprecipitated by rabbit anti-Gemin5 antibody ...read more

Product Details

Summary
Reactivity Hu, Po, Ba, SyHaSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

Gemin 5 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 1410 and 1438 of human gem (nuclear organelle) associated protein 5 using the numbering given in entry NP_056280.1 (GeneID 25929).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GEMIN5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2-5 ug/mg lysate
Theoretical MW
169 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB100-61049 in the following applications:

  • WB
    5 publications

Reactivity Notes

Hamster and Porcine reactivity reported in (PMID: 22362733), Golden Syrian Hamster reported in (PMID: 23221641). Bacteria reactivity reported in scientific literature (PMID: 29771365).

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Gemin 5 Antibody

  • DKFZp586M1824
  • EC 2.7.7.8
  • EC 5.4.2.1
  • gem (nuclear organelle) associated protein 5
  • gem-associated protein 5
  • gemin 5
  • Gemin5
  • MGC142174

Background

GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Gemin 5 Antibody (NB100-61049)(7)

We have publications tested in 3 confirmed species: Human, Bacteria, Golden Syrian Hamster.

We have publications tested in 1 application: WB.


Filter By Application
WB
(5)
All Applications
Filter By Species
Human
(1)
Bacteria
(1)
Golden Syrian Hamster
(1)
All Species
Showing Publications 1 - 7 of 7.
Publications using NB100-61049 Applications Species
Moreno-Morcillo M, Francisco-Velilla R, Embarc-Buh A, et al. Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control Nucleic Acids Res. Dec 4 2019 [PMID: 31799608] (WB) WB
Francisco-Velilla R, Fernandez-Chamorro J, Dotu I, Martinez-Salas E. The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation Nucleic Acids Res. May 16 2018 [PMID: 29771365] (WB, Bacteria) WB Bacteria
Lampe S, Kunze M, Scholz A et al. Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors. Biochim Biophys Acta Gene Regul Mech 2018 Feb [PMID: 29378331] (Human) Human
Francisco-Velilla R, Fernandez-Chamorro J, Ramajo J, Martinez-Salas E. The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. Nucleic Acids Res. Aug 9 2016 [PMID: 27507887] (WB) WB
Fernandez-Chamorro J, Pineiro D, Gordon JM et al. Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation. Nucleic Acids Res. 3/5/2014 [PMID: 24598255] (WB) WB
Pineiro D, Fernandez N, Ramajo J, Martinez-Salas E. Gemin5 promotes IRES interaction and translation control through its C-terminal region Nucleic Acids Res 2012 Dec 5 [PMID: 23221641] (WB, Golden Syrian Hamster) WB Golden Syrian Hamster
Pineiro D, Ramajo J, Bradrick SS, Martinez-Salas E. Gemin5 proteolysis reveals a novel motif to identify L protease targets. Nucleic Acids Res. 2012 Feb 22. [PMID: 22362733]

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Bioinformatics

Gene Symbol GEMIN5
Entrez
Uniprot