Recombinant Human GDF-15 His (N-Term) Protein

Product Discontinued

Recombinant Human GDF-15 His (N-Term) Protein Summary

• Description: Mature human recombiinant GDF-15 protein: aminoacids Ala197-Ile308 with an N-terminal 6-His tag. A biologically active protein GDF15.Source: E. coli
• Details of Functionality: Data is not available.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: GDF15
• Endotoxin Note: Less than 1 EU/ug of the rHuGDF-15 as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 13 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute with sterilized 4 mM HCl to a final concentration of 0.1 mg/ml.. Further dilutions should be made in appropriately buffered solutions.

Alternate Names for Recombinant Human GDF-15 His (N-Term) Protein

• GDF15
• GDF-15
• growth differentiation factor 15
• growth/differentiation factor 15
• Macrophage inhibitory cytokine 1
• MIC-1
• MIC-1NSAID-activated gene 1 protein
• MIC1Prostate differentiation factor
• NAG-1
• NAG-1NSAID-regulated gene 1 protein
• NSAID (nonsteroidal inflammatory drug)-activated protein 1
• PDF
• PDFGDF-15
• PLAB
• PLABNRG-1
• Placental bone morphogenetic protein
• Placental TGF-beta
• PTGF-beta
• PTGFBPTGF-beta

Background

Growth Differentiation Factor 15 (GDF-15) is a divergent member of the TGF-beta superfamily. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein. Human GDF-15 shares 67% aa sequence identity with rat and mouse GDF-15. GDF-15 is expressed in placenta, brain, kidney, pancreas, prostate, and colon. It inhibits macrophage and platelet activation, regulates angiogenesis, and promotes recovery following myocardial infarction. GDF-15 also promotes cartilage formation, neuronal survival, and appetite suppression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: GDF15