GATE-16/GABARAPL2 Antibody

Product Discontinued

GATE-16/GABARAPL2 Antibody Summary

• Immunogen: A synthetic peptide as a part of human, rat, mouse GABA(A) receptor-associated protein-like 2 (GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, FLC3A) conjugated to immunogenic carrier protein has been used as the immunogen.
• Specificity: GABARAPL2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: GABARAPL2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1-10 ug/ml

Reactivity Notes

Human, Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: IgG purified
• Reconstitution Instructions: Reconstitute to desired concentration using sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for GATE-16/GABARAPL2 Antibody

• Apg8p2
• ATG8
• ATG8C
• FLC3A
• GABARAPL2
• gamma-aminobutyric acid receptor-associated protein-like 2
• Ganglioside expression factor 2
• GATE16
• GATE-16
• GEF2
• GEF-2
• GEF2GEF-2
• General Protein Transport Factor P16
• Golgi-Associated ATPase Enhancer Of 16 KDa
• MAP1 light chain 3 related protein
• MAP1 light chain 3-related protein

Background

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. SUBCELLULAR LOCATION: Golgi apparatus. TISSUE SPECIFICITY: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GATE-16/GABARAPL2 Antibody (NB110-74798)(1)

Publication using NB110-74798

• Karanasios E, Ktistakis NT. Studying Autophagy: List of Useful Antibodies Produced via a Community Effort. Autophagy at the Cell, Tissue and Organismal Level. 2016-04-24

FAQs for GATE-16/GABARAPL2 Antibody (NB110-74798). (Showing 1 - 1 of 1 FAQ).

1. I am currently interested in detecting GABARAPL2 by immunofluorescence. Do you have an antibody that I could try out for immunofluorescence
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Bioinformatics

• Gene Symbol: GABARAPL2
• Entrez:
  • 11345(Human)
  • 93739(Mouse)
  • 64670(Rat)
• Uniprot:
  • P60520()