Gastrin-releasing Peptide R/GRPR Antibody - BSA Free

Immunohistochemistry-Paraffin: Gastrin-releasing Peptide R/GRPR Antibody [NLS830] - Staining in stomach tissue.

Immunohistochemistry-Paraffin: Gastrin-releasing Peptide R/GRPR Antibody [NLS830] - Gastrin-releasing Peptide/Bombesin/Neuromedin C Antibody [NLS830] - Analysis of anti-GRPR antibody with human pancreas, islet of Langerhans at 4 ug/ml.

Immunohistochemistry-Paraffin: Gastrin-releasing Peptide R/GRPR Antibody [NLS830] - Gastrin-releasing Peptide/Bombesin/Neuromedin C Antibody [NLS830] - Analysis of anti-GRPR antibody with human lung, non-small cell carcinoma.

Immunohistochemistry-Paraffin: Gastrin-releasing Peptide R/GRPR Antibody [NLS830] - Gastrin-releasing Peptide/Bombesin/Neuromedin C Antibody [NLS830] - Human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Gastrin-releasing Peptide R/GRPR Antibody [NLS830] - Brain Cerebellum Purkinje Neurons

• Reactivity: Hu, Po, Bt, Ca, Eq, Pm, Pm, Rb, Bv
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Gastrin-releasing Peptide R/GRPR Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 18 amino acid peptide from 2nd extracellular domain of human Gastrin-releasing Peptide R/GRPR.
• Epitope: 2nd extracellular domain
• Specificity: Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Bovine (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRPR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4 ug/ml
  • Western Blot 1:1000 - 1:10000
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Mouse (83%), Rat (83%), Hamster (83%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Gastrin-releasing Peptide R/GRPR Antibody - BSA Free

• Gastrin-releasing Peptide R
• gastrin-releasing peptide receptor
• Gastrinreleasing PeptideR
• Gastrin-releasing PeptideR
• GRP-preferring bombesin receptor
• GRPR
• GRP-R

Background

Gastrin-releasing peptide receptor (GRPR) is a Bombesin Receptor. In addition to its involvement in autism and mental retardation, GRPR may also play a role in the progression of cancer. Nicotine exposure induces an increase in GRPR expression in the lung Shriver et al. (2000). GRPR has been reported in brain, breast, colon, lung, lymph node, ovary, placenta, prostate, stomach, and uterus. It has also been shown to be expressed in several cancers, including those in breast, colon, lung, ovary, pancreas, and prostate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Gastrin-releasing Peptide R/GRPR Antibody (NLS830)(2)

Publications using NLS830

• Grimsholm O, Rantapaa-Dahlqvist S, Dalen T, Forsgren S. Observations favouring the occurrence of local production and marked effects of bombesin/gastrin-releasing peptide in the synovial tissue of the human knee joint--comparisons with substance P and the NK-1 receptor. Neuropeptides 2008-04-01 [PMID: 18289674] (Human)
• Grimsholm O, Guo Y, Ny T et al. Are neuropeptides important in arthritis. Studies on the importance of bombesin/GRP and substance P in a murine arthritis model. Ann N Y Acad Sci 2007-09-01 [PMID: 17911468]

Bioinformatics

• Gene Symbol: GRPR
• Entrez:
  • NM_005314(Human)
• Uniprot:
  • P30550(Human)