GABA Transporter 2 Antibody

Product Discontinued

GABA Transporter 2 Antibody Summary

• Immunogen: A 15 residue synthetic peptide derived from C-terminal domain of rat GAT-2
• Specificity: Reacts with GAT-2 from rat, mouse and human central nervous system.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC6A13
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:5 - 1:50
  • Immunohistochemistry-Paraffin 1:5 - 1:50
  • Western Blot 1:20 - 1:500

Reactivity Notes

Cross-reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris-Glycine (pH 7.8) and 50% Glycerol
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Immunogen affinity purified
• Reconstitution Instructions: Lyophilized powder - Must be reconstituted in distilled water.

Alternate Names for GABA Transporter 2 Antibody

• GABA transport protein
• GAT-2
• GAT2Solute carrier family 6 member 13
• sodium- and chloride-dependent GABA transporter 2
• solute carrier family 6 (neurotransmitter transporter, GABA), member 13

Background

GABA is a major inhibitory neurotransmitter and the GABAergic transmission is terminated by the rapid Na+/Cl-dependent uptake of through GABA transporters. There are multiple subtypes of GABA transporters (GAT1, GAT2, GAT3; and betaine GABA transporter (BGT-1). There is 50percent homology between each subtypes. GAT1 and GAT3 have been detected in various parts of the brain while GAT2 is found in many tissues. It appears that GAT1 and GAT3 are involved in distinct GABAergic transmission while GAT2 may be important in non-neural functions. GAT2 is a gamma-amino butyric acid (GABA) transporter. It is a 602 amino acid (85kDa) transmembrane protein

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC6A13
• Entrez:
  • 171163(Rat)
• Uniprot:
  • P31646(Rat)