GABA-A R beta 2 Antibody

Product Discontinued

GABA-A R beta 2 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human GABAA Rbeta2.
• Specificity: GABAA Rbeta2 (R431) pAb detects endogenous levels of GABAA Rbeta2 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GABRB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry Free-Floating
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Use in IHC-FrFl reported in scientific literature (PMID:33218044) Immunohistochemistry (IHC) analyzes of GABAA RBeta2 (R431) pAb in paraffin-embedded human brain tissue. Immunocytochemistry/Immunofluorescence and Western blot were reported in scientific literature.
• Theoretical MW: 59 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GABA-A R beta 2 Antibody

• GABA A R beta 2
• GABA(A) receptor subunit beta-2
• GABAAR beta 2
• GABAARb2
• GABRB2
• gamma-aminobutyric acid (GABA) A receptor, beta 2
• gamma-aminobutyric acid A receptor beta 2
• gamma-aminobutyric acid receptor subunit beta-2
• MGC119386
• MGC119388
• MGC119389

Background

Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GABA-A R beta 2 Antibody (NBP1-51214)(3)

Publications using NBP1-51214

• Kosonsiriluk S, Chaiworakul V, Mauro LJ, El Halawani ME. Enhanced GABAergic inhibition in the premammillary nucleus of photorefractory turkey hens via GABAA receptor upregulation. Gen. Comp. Endocrinol. 2016-04-04 [PMID: 27055929] (IF/IHC, Turkey)
• Kelley MH, Ortiz J, Shimizu K et al. Alterations in Purkinje cell GABA(A) receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of beta(1) -subunit-containing receptors Eur J Neurosci 2012-11-26 [PMID: 23176253] (ICC/IF, IF/IHC, WB, Mouse, Rat)

Bioinformatics

• Gene Symbol: GABRB2
• Uniprot:
  • P47870(Human)