Human and Mouse. Immunogen sequence has 91% identity to bovine.
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Alternate Names for FUS Antibody
75 kDa DNA-pairing protein
amyotrophic lateral sclerosis 6
fused in sarcoma
fusion (involved in t(12;16) in malignant liposarcoma)
fusion gene in myxoid liposarcoma
fusion, derived from t(12;16) malignant liposarcoma
heterogeneous nuclear ribonucleoprotein P2
RNA-binding protein FUS
Translocated in liposarcoma protein
The protein originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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