FUS Antibody (1120264)) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 1120264)
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

FUS Antibody (1120264)) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects recombinant human FUS and human TAF-15 in Direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FUS Antibody (1120264)) [Alexa Fluor™ Plus 555]

• 75 kDa DNA-pairing protein
• ALS6
• altFUS
• amyotrophic lateral sclerosis 6
• ETM4
• FUS
• FUS1
• fused in sarcoma
• fusion (involved in t(12;16) in malignant liposarcoma)
• fusion gene in myxoid liposarcoma
• fusion, derived from t(12;16) malignant liposarcoma
• fus-like protein
• heterogeneous nuclear ribonucleoprotein P2
• HNRNPP2
• Oncogene FUS
• Oncogene TLS
• POMP75
• RNA-binding protein FUS
• TLS
• TLShnRNP-P2
• Translocated in liposarcoma protein

Background

Fused in sarcoma (FUS) is a multifunctional RNA-binding protein with a molecular weight of approximately 68 kDa. FUS belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) and plays critical roles in RNA metabolism, including RNA splicing, transport, translation, and stability. Beyond its functions in RNA handling, FUS contributes to DNA damage repair and transcription regulation, highlighting its importance in cellular homeostasis. FUS is ubiquitously expressed across various tissues, with predominant localization in the nucleus; however, its mislocalization to the cytoplasm is directly implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in the FUS gene have been identified as causative factors in familial ALS, where altered FUS protein function contributes to protein aggregation and neuronal toxicity. Additionally, FUS is involved in cellular stress responses, forming dynamic assemblies known as stress granules under adverse conditions. Aberrant FUS expression or activity has garnered attention as a key biomarker for neurodegenerative disorders and a promising target for therapeutic interventions.

1. Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009 Feb 27;323(5918):1208-1211. doi: 10.1126/science.1165942. PMID: 19251628; PMCID: PMC4516382. 
2. Sama RR, Ward CL, Bosco DA. Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN Neuro. 2014 Jun 1;6(4):1759091414544472. doi: 10.1177/1759091414544472. PMID: 25289647; PMCID: PMC4189536. 
3. Yang S, Warraich ST, Nicholson GA, Blair IP. Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein. Int J Biochem Cell Biol. 2010 Sep;42(9):1408-11. doi: 10.1016/j.biocel.2010.06.003. Epub 2010 Jun 10. PMID: 20541619.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.