Fumarase Antibody (7612) [DyLight 405]

Product Discontinued

Fumarase Antibody (7612) [DyLight 405] Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human Fumarase. The exact sequence is proprietary.
• Predicted Species: Porcine (98%), Bovine (98%), Zebrafish (90%), Primate (99%), Sheep (99%), Chicken (91%). Backed by our 100% Guarantee.
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse
• Gene: FH
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Chimpanzee (99%).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for Fumarase Antibody (7612) [DyLight 405]

• EC 4.2.1.2
• fumarase
• fumarate hydratase
• fumarate hydratase, mitochondrial
• HLRCC
• LRCC
• MCL
• MCUL1

Background

Fumarase is encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FH