Hu, Mu, Rt, Po, Bv, Ch, Pm, Sh, ZeApplications:
WB, ICC/IF, IHC, IHC-PHost:
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, KD
Host: Rabbit Polyclonal
Species: Hu, Rt, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Applications: Func, PAGE, Bioactivity
Fumarase is encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Bioinformatics Tool for Fumarase
Discover related pathways, diseases and genes to Fumarase. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.