FPRL1/FPR2 Antibody (304405) [Phycoerythrin]

Human peripheral blood monocytes were stained with Mouse Anti-Human FPRL1/FPR2 PE-conjugated Monoclonal Antibody (Catalog # FAB3479P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 304405
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

FPRL1/FPR2 Antibody (304405) [Phycoerythrin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human FPRL1/FPR2
  Met1-Met351
  Accession # P25090
• Specificity: Stains FPRL1/FPR2 transfectants but not irrelevant transfectants. It also stains monocytes and granulocytes.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: FPR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FPRL1/FPR2 Antibody (304405) [Phycoerythrin]

• ALXR
• FMLP-R-I
• FMLP-R-II
• FMLPX
• formyl peptide receptor 2
• Formyl peptide receptor-like 1RFP
• FPR2
• FPR2A
• FPRH1FMLP-related receptor I
• FPRL1
• FPRL1LXA4 receptor
• HM63
• HM63FPRH2
• lipoxin A4 receptor (formyl peptide receptor related)
• Lipoxin A4 receptor
• LXA4 Receptor
• LXA4RFMLP-R-I
• N-formyl peptide receptor 2
• RFP

Background

FPRL1, also known as FPR2, is a 7TM protein expressed on mononuclear phagocytes and microglial cells. It interacts with formyl peptides to attract phagocytes to sites of infection and promote inflammatory reactions. FPRL1 also interacts with amyloid beta peptides and has been implicated in phagocyte attraction to sites of amyloid plaques in Alzheimer’s disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FPRL1/FPR2 Antibody (FAB3479P)(10)

Publications using FAB3479P

• Klatte-Schulz, F;Bormann, N;Bonell, A;Al-Michref, J;Nguyen, HL;Klöckner, P;Thiele, K;Moroder, P;Seifert, M;Sawitzki, B;Wildemann, B;Duda, GN; Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved? Cells 2023-12-20 [PMID: 38201221] (Flow Cytometry, Human)
• L Vecchi, STS Mota, MAP Zóia, IC Martins, JB de Souza, TG Santos, AO Beserra, VP de Andrade, LR Goulart, TG Araújo Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment Cells, 2022-05-20;11(10):. 2022-05-20 [PMID: 35626741] (Flow Cytometry, Human)
• Jamie D. Kraft, Robert Blomgran, Ida Bergström, Matúš Soták, Madison Clark, Alankrita Rani et al. Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis The FASEB Journal 2022-03-01 [PMID: 35104001]
• B Jundi, DH Lee, H Jeon, MG Duvall, J Nijmeh, RE Abdulnour, M Pinilla-Ve, RM Baron, J Han, J Voldman, BD Levy Inflammation resolution circuits are uncoupled in acute sepsis and correlate with clinical severity JCI Insight, 2021-08-09;0(0):. 2021-08-09 [PMID: 34166226] (Flow Cytometry, Human)
• N Novizio, R Belvedere, E Pessolano, A Tosco, A Porta, M Perretti, P Campiglia, A Filippelli, A Petrella Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors Cells, 2020-12-18;9(12):. 2020-12-18 [PMID: 33353163] (Flow Cytometry, Human)
• STS Mota, L Vecchi, DA Alves, AO Cordeiro, GS Guimarães, E Campos-Fer, YCP Maia, BC Dornelas, SM Bezerra, VP de Andrade, LR Goulart, TG Araújo Annexin A1 promotes the nuclear localization of the epidermal growth factor receptor in castration-resistant prostate cancer Int. J. Biochem. Cell Biol., 2020-08-25;127(0):105838. 2020-08-25 [PMID: 32858191] (Flow Cytometry, Human)
• YC Chen, MC Lin, CH Lee, SF Liu, CC Wang, WF Fang, TY Chao, CC Wu, YF Wei, HC Chang, CC Tsen, HC Chen Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease J Transl Med, 2018-03-15;16(1):69. 2018-03-15 [PMID: 29544524] (Flow Cytometry, Human)
• Clark GJ et al. New insights into the phenotype of human dendritic cell populations. Clin Transl Immunology 1/1/2016 [PMID: 26900474]
• Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MS Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. Am. J. Pathol., 2010-08-13;177(4):2116-23. 2010-08-13 [PMID: 20709806] (Flow Cytometry, Human)
• McDermott DH, De Ravin SS, Jun HS Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. Blood, 2010-07-08;116(15):2793-802. 2010-07-08 [PMID: 20616219] (Flow Cytometry, Human)

Review for FPRL1/FPR2 Antibody (FAB3479P) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: izzy livnebar IF Mouse 03/17/2016

Summary

• Application: Immunofluorescence
• Species: Mouse
• Lot: A-2

FAQs for FPRL1/FPR2 Antibody (FAB3479P). (Showing 1 - 1 of 1 FAQs).

1. I am looking for an FPRL1 antibody that is reactive to mouse only. Does Novus have the antibody in question?
   • To answer your question, unfortunately all our FPRL1 antibodies are polyclonal and would detect both mouse and human formyl peptide receptor-like-1 and we do not have any mouse monoclonal antibody for it.

Bioinformatics

• Gene Symbol: FPR2
• Uniprot:
  • P25090()