FPRL1/FPR2 Antibody (304405) [Fluorescein]

Human peripheral blood monocytes were stained with Mouse Anti-Human FPRL1/FPR2 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB3479F, filled histogram) or isotype control antibody (Catalog # IC0041F, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 304405
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Fluorescein

FPRL1/FPR2 Antibody (304405) [Fluorescein] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human FPRL1/FPR2
  Met1-Met351
  Accession # P25090
• Specificity: Stains FPRL1/FPR2 transfectants but not irrelevant transfectants. It also stains monocytes and granulocytes.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: FPR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FPRL1/FPR2 Antibody (304405) [Fluorescein]

• ALXR
• FMLP-R-I
• FMLP-R-II
• FMLPX
• formyl peptide receptor 2
• Formyl peptide receptor-like 1RFP
• FPR2
• FPR2A
• FPRH1FMLP-related receptor I
• FPRL1
• FPRL1LXA4 receptor
• HM63
• HM63FPRH2
• lipoxin A4 receptor (formyl peptide receptor related)
• Lipoxin A4 receptor
• LXA4 Receptor
• LXA4RFMLP-R-I
• N-formyl peptide receptor 2
• RFP

Background

FPRL1, also known as FPR2, is a 7TM protein expressed on mononuclear phagocytes and microglial cells. It interacts with formyl peptides to attract phagocytes to sites of infection and promote inflammatory reactions. FPRL1 also interacts with amyloid beta peptides and has been implicated in phagocyte attraction to sites of amyloid plaques in Alzheimer’s disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FPRL1/FPR2 Antibody (FAB3479F)(4)

Publications using FAB3479F

• AP Tosolini, JN Sleigh, S Surana, ER Rhymes, SD Cahalan, G Schiavo BDNF-dependent modulation of axonal transport is selectively impaired in ALS Acta neuropathologica communications, 2022-08-22;10(1):121. 2022-08-22 [PMID: 35996201] (Western Blot, Mouse)
• LC Wang, SR Wu, HW Yao, P Ling, GC Perng, YC Chiu, SM Hsu, SH Chen Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice PloS Pathogens, 2022-08-08;18(8):e1010692. 2022-08-08 [PMID: 35939498] (Flow Cytometry, Human)
• M Sekheri, D El Kebir, N Edner, JG Filep 15-Epi-LXA4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation Proc. Natl. Acad. Sci. U.S.A., 2020-03-23;0(0):. 2020-03-23 [PMID: 32205444] (Flow Cytometry, Human)
• Y Yang, H Choi, M Seon, D Cho, SI Bang LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway Stem Cell Res Ther, 2016-04-19;7(1):58. 2016-04-19 [PMID: 27095351] (Flow Cytometry, Human)

FAQs for FPRL1/FPR2 Antibody (FAB3479F). (Showing 1 - 1 of 1 FAQs).

1. I am looking for an FPRL1 antibody that is reactive to mouse only. Does Novus have the antibody in question?
   • To answer your question, unfortunately all our FPRL1 antibodies are polyclonal and would detect both mouse and human formyl peptide receptor-like-1 and we do not have any mouse monoclonal antibody for it.

Bioinformatics

• Gene Symbol: FPR2
• Uniprot:
  • P25090()