FPRL1/FPR2 Products

Description

FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.

Bioinformatics

Entrez	2358 Human
Uniprot	P25090
Product By Gene ID	2358
Alternate Names	ALXR FMLP-R-I FMLP-R-II FMLPX formyl peptide receptor 2 Formyl peptide receptor-like 1RFP FPR2 FPR2A FPRH1FMLP-related receptor I FPRL1 FPRL1LXA4 receptor HM63 HM63FPRH2 lipoxin A4 receptor (formyl peptide receptor related) Lipoxin A4 receptor LXA4 Receptor LXA4RFMLP-R-I N-formyl peptide receptor 2 RFP

Research Areas for FPRL1/FPR2

Find related products by research area and learn more about each of the different research areas below.

GPCR
Immunology