FoxP2 Antibody (RB21207)

Product Discontinued

FoxP2 Antibody (RB21207) Summary

• Immunogen: This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-684 amino acids from the C-terminal region of human FOXP2.
• Localization: Cellular Location Nucleus (Probable). Tissue Location Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FOXP2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Western Blot 1:1000
• Theoretical MW: 79.919 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Predicted to react with Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 0.98 mg/ml
• Purity: Protein A purified

Alternate Names for FoxP2 Antibody (RB21207)

• CAG repeat protein 44
• CAGH44
• CAGH44TNRC10forkhead box protein P2
• DKFZp686H1726
• forkhead box P2
• forkhead/winged-helix transcription factor
• FoxP2
• SPCH1
• TNRC10
• trinucleotide repeat containing 10
• Trinucleotide repeat-containing gene 10 protein

Background

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FOXP2
• Uniprot:
  • O15409()
  • O15409()