FoxH1 Antibody

Product Discontinued

FoxH1 Antibody Summary

• Immunogen: Synthetic peptide surrounding amino acid 55 of mouse FoxH1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FOXH1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 0.5% BSA and 30% Glycerol
• Preservative: 0.01% Thimerosal
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FoxH1 Antibody

• FAST1
• Fast-1
• FAST1forkhead box protein H1
• FAST2
• Fast-2
• Forkhead activin signal transducer 1
• Forkhead activin signal transducer 2
• forkhead activin signal transducer-1
• forkhead box H1
• FoxH1
• hFAST-1
• TGF-beta/activin signal transducer

Background

Fas, also referred to as CD95 or APO-1, is a type I transmembrane protein that plays a central role mediating viral immunity. TIA-1 and TIAR are two closely related proteins that possess three RRMs (RNA recognition motifs), designated RRM 1, 2 and 3, respectively. Although both TIA-1 and TIAR are thought to function as mediators of apoptotic cell death, their specific roles in such pathways are unknown. Unlike TIA-1, which is found in the granules of cytotoxic lymphocytes, TIAR expression is limited to the nucleus and found in a much broader range of cells including, but not limited to, cells of hematopoietic origin. TIAR is translocated to the cytoplasm shortly after Fas ligation and this event immediately proceeds the onset of DNA fragmentation. A novel serine/ threonine kinase that is activated as a result of Fas ligation, designated FAST (Fas-activated serine/threonine), shows kinase specificity towards both TIA-1 and TIAR. In unstimulated Jurkat cells, FAST resides in the cytoplasm as a highly phosphorylated protein and is quickly dephosphorylated and activated in response to stimulated Fas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: FOXH1
• Entrez:
  • 8928(Human)
  • 14106(Mouse)
  • 300054(Rat)
• Uniprot:
  • O88621(Mouse)