FosB/G0S3 Antibody (83B1138) - Azide Free

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Western Blot: FosB/G0S3 Antibody (83B1138) - Azide Free [NBP2-33219] - Analysis of FosB in HeLa cell lysate where bands are observed at ~38 kDa representing FosB and at ~35 kDa representing delta FosB. Image from the ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
83B1138
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide Free
Concentration
0.5 mg/ml

Order Details

FosB/G0S3 Antibody (83B1138) - Azide Free Summary

Immunogen
This antibody was generated by immunizing mice with a synthetic peptide corresponding to amino acids 2-15 of human FosB.
Specificity
In HeLa, a 46 kDa band is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FOSB
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS - BSA free
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for FosB/G0S3 Antibody (83B1138) - Azide Free

  • activator protein 1
  • AP-1
  • DKFZp686C0818
  • FBJ murine osteosarcoma viral oncogene homolog B
  • FosB
  • G0S3
  • G0S3G0/G1 switch regulatory protein 3
  • GOS3
  • GOSB
  • MGC42291
  • oncogene FOS-B
  • protein fosB

Background

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FOSB