FosB/G0S3 Products

Description

The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a 62 kDa nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo and heterodimers, which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine FosB encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and FosB include Fra-1 and Fra-2 genes.

Bioinformatics

Entrez	2354 Human
Uniprot	P53539
Product By Gene ID	2354
Alternate Names	activator protein 1 AP-1 DKFZp686C0818 FBJ murine osteosarcoma viral oncogene homolog B FosB G0S3 G0S3G0/G1 switch regulatory protein 3 GOS3 GOSB MGC42291 oncogene FOS-B protein fosB

Research Areas for FosB/G0S3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors