After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.
CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
Species: Hu Applications: WB, IHC, ICC/IF Host: Goat Polyclonal
HAF007). A specific band was detected for FosB/G0S3 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
Species: Hu Applications: WB Host: Mouse Monoclonal
Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
![Immunocytochemistry FosB/G0S3 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/FosB_AF2214_Immunocytochemistry__Immunofluorescence_21634.jpg)
![Western Blot FosB/G0S3 Antibody (269928) [Unconjugated]](http://images.novusbio.com/images/antibody/FosB_MAB2214_Western_Blot_6019.jpg)
![Immunohistochemistry FosB/G0S3 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/FosB_AF2214_Immunohistochemistry_9938.jpg)
