Recombinant Human FGFR2 alpha (IIIc), Fc Protein

Product Discontinued

Recombinant Human FGFR2 alpha (IIIc), Fc Protein Summary

• Description: A disulfide-linked homodimeric protein corresponding to Arg22 - Glu377 & Leu27 - Glu377 (N-terminal Human FGF R2 alpha IIIc #P21802), IEGRMD, and Pro100 - LYs330 (C-terminal Human IgG1) of FGF R2 alpha.
  
  

  Source: Mouse myeloma cell line, NS0-derived

• Preparation Method: Lyophilized from a 0.2 um filtered solution in PBS.
• Details of Functionality: Measured by its ability to inhibit FGF acidic dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is typically 0.5-2 ng/mL.
• Protein/Peptide Type: Recombinant Protein
• Gene: FGFR2
• Purity: SDS-PAGE
• Endotoxin Note: <0.10 EU per 1 ug of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 16.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: SDS-PAGE
• Reconstitution Instructions: Reconstitute with 0.1 mg/ml in sterilized PBS to desired concentration.

Alternate Names for Recombinant Human FGFR2 alpha (IIIc), Fc Protein

• BBDS;BEK;BFR-1;CD332;CEK3;CFD1;ECT1;Fibroblast growth factor receptor;Fibroblast growth factor receptor 2;JWS;KGFR;K-SAM;Receptor protein-tyrosine kinase;TK14;TK25
• FGF R2a
• FGFR2 alpha

Background

Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that are potent physiological regulators of growth and differentiation for a wide variety of cells of mesodermal, ectodermal and endodermal origin. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1, FGFR2, FGFR3 and FGFR4. FGFRs are members of the tyrosine kinase family of growth factor receptors. FGFR2 is highly expressed in developing human tissues including the brain, choroids plexus, lung etc.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: FGFR2