Recombinant Human FGF-BP Protein

Product Discontinued

Recombinant Human FGF-BP Protein Summary

• Description: A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 24-234 of Human FGF-BP
  
  

  Source: E.coli

  Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: FGFBP1
• Purity: >85%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 26.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 10% glycerol, 1 mM DTT
• Preservative: No Preservative
• Concentration: 0.25 mg/ml
• Purity: >85%, by SDS-PAGE

Alternate Names for Recombinant Human FGF-BP Protein

• 17 kDa heparin-binding growth factor-binding protein
• FGFBP
• FGF-BP
• FGFBP1
• FGF-BP1
• FGFBP-1
• FGFBPFGF-binding protein 1
• fibroblast growth factor binding protein 1
• fibroblast growth factor-binding protein 1
• HBp17
• HBP1717 kDa HBGF-binding protein
• heparin-binding growth factor binding protein

Background

FGFBP1, also known as Fibroblast growth factor-binding protein 1, is a 234 amino acid protein that is approximately 26 kDa, acts as a carrier protein that release fibroblast-binding factors (FGFs) enhancing its mitogenic activity and can be found secreted, in extracellular space and cell membrane. This protein is currently being studied for research on the following diseases and disorders: squamous cell carcinoma, breast cancer, colon cancer, pancreatitis, hypertension, narcolepsy, ataxia, prostatitis, and peritonitis. FGFBP1 has also been shown to have interactions with FGF2, FIBP, NRP2, UBQLN4 and HSPG2 in pathways such as the positive regulation of fibroblast growth factor receptor signaling pathway, positive and negative regulation of cell proliferation, cell-cell signaling and signal transduction.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: FGFBP1