Fer Antibody (690318) [Alexa Fluor® 350]

• Applications: IHC
• Clone: 690318
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Fer Antibody (690318) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Fer
  Asn93-Ala302
  Accession # P16591
• Specificity: Detects human Fer in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

FER [feline encephalitis virus (FES)-related kinase], also called Tyk3, is a widely expressed 822 amino acid (aa), 94 kDa intracellular non-receptor tyrosine kinase of the FES/FPS family. Human FER contains an FCH (microtubule/cytoskeleton interaction) domain (aa 1‑58), a coiled coil oligomerization region, an SH2 domain (aa 460‑550) and a kinase domain (aa 563‑816). FER is found both in the cytoplasm and the nucleus, and interacts with several transmembrane receptors, cytosolic proteins, and nuclear chromatin. Through its interactions and kinase activity, Tyk3/FER influences synapse formation, cytoskeletal rearrangement, cell survival and cell cycle progression. Within the region used as an immunogen, human Tyk3/FER shares 97% aa sequence identity with mouse Tyk3/FER. Potential human Tyk3/FER isoforms truncated at aa 308 and 478 have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.