FCGR2C Antibody (190710) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: ELISA(Cap), ELISA(Det)
• Clone: 190710
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

FCGR2C Antibody (190710) [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Fcγ RIIB/C
  Ala46-Pro217
  Accession # P31994
• Specificity: Detects human Fc gamma RIIB/C in ELISAs. In a sandwich ELISA shows approximately 40% cross-reactivity with recombinant human (rh) Fc gamma RIIA and no cross‑reactivity with rhFc gamma RI, rmFc gamma RI, rmFc gamma RIIB, rhFc gamma RIIIB, rmFc gamma RIII, or rmFcrl3/CD16-2.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FCGR2C Antibody (190710) [Alexa Fluor® 532]

• low affinity immunoglobulin gamma Fc region receptor II-c
• CD32
• CD32c
• CDW32
• Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
• Fc gamma RIIC
• FCG2
• FCGR2C
• FcgRIIC
• FCRIIC
• IGFR2

Background

Fc gamma RII, also known as CD32, is a group of three closely related proteins (Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIC) that share greater than 94% amino acid identity in their extracellular domains with Fc gamma RIIB and Fc gamma RIIC having identical extracellular domains. They function as transmembrane receptors for the Fc portion of IgG molecules. These proteins are expressed by various hematopoietic cells including monocytes, macrophages, neutrophils, NK, T and B cells. The Fc gamma RII proteins are involved in phagocytosis of immune complexes and modulation of antibody production by B cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.