FCAR/CD89 Antibody

Western Blot: CD89 Antibody [NBP2-15820] - Sample (30 ug of whole cell lysate) A: Raji B: K562 5% SDS PAGE gel, diluted at 1:1000.

Immunohistochemistry-Paraffin: FCAR/CD89 Antibody [NBP2-15820] - Staining at cytoplasm in human cervical carcinoma.

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

FCAR/CD89 Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human FCAR/CD89. The exact sequence is proprietary.
• Localization: Isoform A; 1: Cell membrane; Single-pass type I membrane protein; 2: Cell membrane; Single-pass type I membrane protein; 3: Cell membrane; Single-pass type I membrane protein; Isoform B: Secreted; Isoform B-delta-S2: Secreted
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FCAR
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 32 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS, 1% BSA, 20% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Antigen Affinity-purified

Alternate Names for FCAR/CD89 Antibody

• CD89 antigen
• CD89
• CD89IgA Fc receptor
• Fc alpha receptor
• Fc fragment of IgA, receptor for
• FCAR
• immunoglobulin alpha Fc receptor

Background

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: FCAR
• Uniprot:
  • P24071()