Fc gamma RIIB/CD32b Antibody Summary
Synthetic peptide C-PDALEEPDDQNRI from the C-terminus of human FCGR2B / CD32B (NP_003992.3; NP_001002273.1; NP_001002274.1; NP_001002275.1; NP_001177757.1).
Human FCGR2B / CD32B. This antibody is expected to recognise all reported isoforms (NP_001002273.1; NP_001002274.1; NP_001002275.1; NP_003992.3; NP_001177757.1).
Primate (100%), Monkey (92%). Backed by our 100% Guarantee.
Immunogen affinity purified
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- Western Blot 0.3-1 ug/ml
- ELISA 1:16000
- Immunohistochemistry-Paraffin 3.75 ug/ml
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for Fc gamma RIIB/CD32b Antibody
- CD32 antigen
- CD32Fc fragment of IgG, low affinity II, receptor for (CD32)
- Fc fragment of IgG, low affinity IIb, receptor (CD32)
- Fc fragment of IgG, low affinity IIb, receptor for (CD32)
- Fc gamma RIIB
- Fc-gamma RII-b
- IgG Fc receptor II-b
- low affinity immunoglobulin gamma Fc region receptor II-b
Low affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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