Fc gamma RIIB/CD32b Products

Description

Low affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis.

Bioinformatics

Entrez	14130 Mouse 2213 Human 289211 Rat
Uniprot	NP_001002273.1 Human NP_001002274.1 Human NP_001002275.1 Human NP_001177757.1 Human NP_003992.3 Human
Product By Gene ID	2213
Alternate Names	CD32 antigen CD32B CD32Fc fragment of IgG, low affinity II, receptor for (CD32) CDw32 Fc fragment of IgG, low affinity IIb, receptor (CD32) Fc fragment of IgG, low affinity IIb, receptor for (CD32) Fc gamma RIIb FCG2 Fc-gamma RII-b fc-gamma-RIIb Fc-gamma-RIIb FCGR2 fcRII-b FcRII-b IGFR2 IgG Fc receptor II-b low affinity immunoglobulin gamma Fc region receptor II-b

Research Areas for Fc gamma RIIB/CD32b

Find related products by research area and learn more about each of the different research areas below.

Immunology
Phospho-Specific