Factor XIIIa Antibody

ELISA: Factor XIIIa Antibody [33190002]

Product Discontinued

Factor XIIIa Antibody Summary

• Immunogen: This antibody is specific for the C Terminus Region of the target protein.
• Marker: Dendritic Cell Marker
• Specificity: This product is specific for Human F13A1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: F13A1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
• Application Notes: This antibody is useful in ELISA.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for Factor XIIIa Antibody

• bA525O21.1 (coagulation factor XIII, A1 polypeptide)
• coagulation factor XIII A chain
• coagulation factor XIII, A1 polypeptide
• Coagulation factor XIIIa
• EC 2.3.2.13
• F13A
• F13A1
• F13Acoagulation factor XIII, A polypeptide
• factor XIIIa
• fibrin stabilizing factor, A subunit
• fibrinoligase
• FSF, A Subunit
• Protein-glutamine gamma-glutamyltransferase A chain
• TGase
• Transglutaminase A chain
• transglutaminase. plasma

Background

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine cross linking between fibrin molecules, thus stabilizing the fibrin clot. It also cross links alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Factor XIIIa Antibody (33190002)(2)

Publications using 33190002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: F13A1
• Entrez:
  • 2162(Human)
• Uniprot:
  • P00488(Human)