Factor XIIIa Products

Antibodies
Factor XIIIa Antibody (6F5)
Factor XIIIa Antibody (6F5)
Species: Hu
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Factor XIIIa Antibody
Factor XIIIa Antibody
NB100-93395
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Factor XIIIa Antibody (M1)
Factor XIIIa Antibody (M1)
H00002162-M02
Species: Hu
Applications: ELISA, PLA
Host: Mouse Monoclonal
Antibody Pairs
Factor XIIIa Antibody Pair
Factor XIIIa Antibody Pair
H00002162-PW1
Species: Hu
Applications: WB, IP
Lysates
Factor XIIIa Overexpression L ...
Factor XIIIa Overexpression Lysate...
H00002162-T01
Species: Hu
Applications: WB
Factor XIIIa Overexpression L ...
Factor XIIIa Overexpression Lysate...
NBL1-10406
Applications: WB
Proteins
Factor XIIIa Recombinant Prot ...
Factor XIIIa Recombinant Protein
H00002162-P01
Species: Hu
Applications: WB, ELISA, PA
Factor XIIIa Recombinant Prot ...
Factor XIIIa Recombinant Protein A...
NBP1-83938PEP
Species: Hu
Applications: AC
RNAi
Factor XIIIa RNAi
Factor XIIIa RNAi
H00002162-R01
Species: Hu

Description

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2162
Alternate Names
  • bA525O21.1 (coagulation factor XIII, A1 polypeptide)
  • transglutaminase. plasma
  • TGase
  • FSF, A subunit
  • EC 2.3.2.13
  • fibrinoligase
  • Transglutaminase A chain
  • fibrin stabilizing factor, A subunit
  • Protein-glutamine gamma-glutamyltransferase A chain
  • factor XIIIa
  • Coagulation factor XIIIa
  • F13Acoagulation factor XIII, A polypeptide
  • coagulation factor XIII A chain
  • coagulation factor XIII, A1 polypeptide

Research Areas for Factor XIIIa

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology

PTMs for Factor XIIIa

Learn more about PTMs related to Factor XIIIa.

Methylation

Bioinformatics Tool for Factor XIIIa

Discover related pathways, diseases and genes to Factor XIIIa. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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