Exostosin-like 3/EXTL3 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: mFluor Violet 610 SE

Exostosin-like 3/EXTL3 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Exostosin-like 3/EXTL3 Lumenal Domain
  Thr52-Ile919
  Accession # O43909
• Specificity: Detects human Exostosin-like 3/EXTL3 Lumenal Domain in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: EXTL3
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Exostosin-like 3/EXTL3 Antibody [mFluor Violet 610 SE]

• botv
• DKFZp686C2342
• EC 2.4.1.223
• exostoses (multiple)-like 3
• Exostosin like 3
• Exostosin-like 3
• EXTL1L
• EXTL3
• EXTR1BOTV
• EXT-related protein 1
• Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• Hereditary multiple exostoses gene isolog
• KIAA0519
• Multiple exostosis-like protein 3
• Putative tumor suppressor protein EXTL3
• reg receptor
• REG
• REGR
• RPR

Background

EXTL3, also referred to as Exostosin-like 3, is a glycosyltransferase and a critical player in the control of keratinocyte proliferation and differentiation via its interaction with REG3A. EXTL3 is 919 amino acids in length and approximately 105kDa. Current research surrounding EXTL3 has shown a possible link with several diseases and disorders such as colorectal cancer, HIV, hepatitis, gonorrhea, syphilis, exostosis, pancreatitis and rheumatic aortic stenosis. EXTL3 has also been shown to interact with Fyn, Crk, Phospholipase C gamma 1, PI 3 Kinase p85 alpha, and PEPP2 in pathways such as Glycosaminoglycan biosynthesis, heparan sulfate biosynthesis, the activation of Chaperones by IRE1alpha, and protein metabolism pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EXTL3