Exostosin-like 3/EXTL3 Antibody (311007) [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: WB, IP
• Clone: 311007
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

Exostosin-like 3/EXTL3 Antibody (311007) [Janelia Fluor® 646] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Exostosin-like 3/EXTL3
  Thr52-Ile919
  Accession # O43909
• Specificity: Detects human Exostosin-like 3/EXTL3 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: EXTL3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Exostosin-like 3/EXTL3 Antibody (311007) [Janelia Fluor® 646]

• botv
• DKFZp686C2342
• EC 2.4.1.223
• exostoses (multiple)-like 3
• Exostosin like 3
• Exostosin-like 3
• EXTL1L
• EXTL3
• EXTR1BOTV
• EXT-related protein 1
• Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• Hereditary multiple exostoses gene isolog
• KIAA0519
• Multiple exostosis-like protein 3
• Putative tumor suppressor protein EXTL3
• reg receptor
• REG
• REGR
• RPR

Background

EXTL3, also referred to as Exostosin-like 3, is a glycosyltransferase and a critical player in the control of keratinocyte proliferation and differentiation via its interaction with REG3A. EXTL3 is 919 amino acids in length and approximately 105kDa. Current research surrounding EXTL3 has shown a possible link with several diseases and disorders such as colorectal cancer, HIV, hepatitis, gonorrhea, syphilis, exostosis, pancreatitis and rheumatic aortic stenosis. EXTL3 has also been shown to interact with Fyn, Crk, Phospholipase C gamma 1, PI 3 Kinase p85 alpha, and PEPP2 in pathways such as Glycosaminoglycan biosynthesis, heparan sulfate biosynthesis, the activation of Chaperones by IRE1alpha, and protein metabolism pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EXTL3