EVER2 Antibody [Alexa Fluor™ Plus 647]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 647

EVER2 Antibody [Alexa Fluor™ Plus 647] Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide from near the center of human EVER2. The immunogen is located within amino acids 300 - 350 of EVER2. Amino Acid Squence: WATKYSQDNKEESL
• Specificity: At least three isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TMC8
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for EVER2 Antibody [Alexa Fluor™ Plus 647]

• epidermodysplasia verruciformis 2
• Epidermodysplasia verruciformis protein 2
• EV2
• EVER2MGC102701
• EVIN2FLJ43684
• FLJ40668
• MGC40121
• transmembrane channel-like 8
• transmembrane channel-like protein 8

Background

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Expressed in placenta, prostate and testis. DISEASE: Defects in TMC8 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TMC8