ER beta/NR3A2 Antibody (3F3)

Product Discontinued

ER beta/NR3A2 Antibody (3F3) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: ESR2 (NP_001428, 22 a.a. - 121 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNR
• Specificity: ESR2 (3F3)
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ESR2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ER beta/NR3A2 Antibody (3F3)

• ER beta
• Erb
• ER-beta
• ESR2
• ESR-BETA
• ESTRB
• estrogen receptor 2 (ER beta)
• estrogen receptor beta 4
• estrogen receptor beta
• NR3A2
• NR3A2ESRB
• Nuclear receptor subfamily 3 group A member 2

Background

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ER beta/NR3A2 Antibody (H00002100-M01)(2)

Publications using H00002100-M01

• Shridharan RN, Krishnagiri H, Govindaraj V et al. Neonatal exposure to estradiol-17beta modulates tumour necrosis factor alpha and cyclooxygenase-2 expression in brain and also in ovaries of adult female rats. Horm Mol Biol Clin Investig 2016-02-01 [PMID: 26872318]
• Radhika NS, Govindaraj V, Sarangi SK, Rao AJ. Neonatal exposure to 17b-estradiol down-regulates the expression of synaptogenesis related genes in selected brain regions of adult female rats. Life Sci. 2015-09-24 [PMID: 26409312]

Bioinformatics

• Gene Symbol: ESR2
• Entrez:
  • 2100(Human)
• OMIM:
  • 601663(Human)
• Uniprot:
  • NP_001428()