Eps8 Antibody [Alexa Fluor® 488]

• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

Eps8 Antibody [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Eps8
  Met1-Ser177
  Accession # Q12929
• Specificity: Detects endogenous human Eps8 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Eps8 (EGF R pathway substrate 8) is a 97 kDa member of the Eps family of proteins. It is ubiquitously expressed and serves as a signaling molecule for multiple RTKs, including FGF R, EGF R and PDGF R. Upon activation, Eps8 promotes endocytosis through Rab5, and Rac activation via IRSp53, Abi-1 and Sos-1. Human Eps8 is 822 amino acids (aa) in length. It contains a PH-like domain (aa 62‑173), an EGF R binding region (aa 296‑362), an SH3 domain that mediates homodimerization (aa 535‑587) and a Sos-1 interaction site (aa 648‑821). There is one potential alternate start site at Met261, and a splice variant that shows a 15 aa substitution for aa 676‑822.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.