Epiregulin Antibody (870110R) [Unconjugated]

Images

 
There are currently no images for Epiregulin Antibody (MAB14253R).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N
Clone
870110R
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Epiregulin Antibody (870110R) [Unconjugated] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
E. coli-derived recombinant human Epiregulin
Val63-Leu108
Accession # O14944
Specificity
Detects human Epiregulin in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from cell culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Neutralization 0.4-4 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Epiregulin Antibody (870110R) [Unconjugated]

  • Epiregulin
  • ER
  • EREG
  • proepiregulin

Background

Epiregulin is a member of the EGF family of growth factors which includes, among others, epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, amphiregulin (ARG), HB (heparin-binding)-EGF, betacellulin, and the various heregulins. All EGF family members are synthesized as transmembrane precursors and are converted to soluble forms by proteolytic cleavage. Epiregulin was originally purified from the mouse fibroblast-derived tumor cell line NIH3T3/T7 (1). The human epiregulin cDNA encodes a 169 amino acid (aa) residues transmembrane precursor with a 29 aa signal peptide, a 21 aa transmembrane domain and a 21 aa cytoplasmic domain. The putative soluble mature Epiregulin comprising the EGF-like domain (aa residues 64‑104) is formed by proteolytic removal of the propeptide regions (2). There is 85% aa sequence homology between human and mouse epiregulins. Epiregulin is expressed primarily in the placenta and macrophages (3). High level expression has also been detected in various carcinomas. Epiregulin specifically binds EGFR (ErbB1) and ErbB4 but not ErbB2 and ErbB3. It activates the homodimers of both ErbB1 and ErbB4. In addition, epiregulin can also activate all possible heteromeric combinations of the four ErbB family members (4). Epiregulin stimulates the proliferation of fibroblasts, smooth muscle cells and hepatocytes. It has been shown to be an autocrine growth factor for epidermal keratinocytes as well as mesangial cells (5, 6). Epiregulin has also been shown to inhibit growth of several epithelial tumor cells. In addition, Epiregulin has been implicated in the implantation process during pregnancy (7).

  1. Toyoda, H. et al. (1995) J. Biol. Chem. 270:7495.
  2. Toyoda, H. et al. (1997) Biochem. J. 326:69.
  3. Komurasaki, T. et al. (1997) Oncogene 15:2841.
  4. Shelly, M. et al. (1998) J. Biol. Chem. 273:10496.
  5. Shirakata, Y. et al. (2000) J. Biol. Chem. 275:5748.
  6. Mishre, R. et al. (2002) Am. J. Physiol. Renal. Physiol. 283:F1151.
  7. Das, S.K. et al. (1997) Dev. Biol. 190:178.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-50599
Species: Hu
Applications: WB, ELISA, Flow, IHC, IP, CyTOF-ready
NBP1-97507
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-P
NBP1-85466
Species: Hu, Mu, Fe
Applications: WB, IHC, IHC-P
NB100-1598
Species: Hu, Mu
Applications: WB, Flow, ICC/IF
NBP1-88220
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, KD
NBP2-67605
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP2-98675
Species: Hu
Applications: WB, IHC, IHC-P, IP
NBP1-48002
Species: Hu, Ca, Pm, Pm
Applications: WB, ICC/IF, IHC, IHC-P, IP
AF3894
Species: Mu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ICC
NB100-56146
Species: Hu
Applications: WB, IHC, IHC-P, IP
MAB1936
Species: Hu
Applications: WB, IP
NBP2-22203
Species: Hu, Mu, Rt, Pm
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
NBP2-38770
Species: Hu, Mu
Applications: WB
NB100-689
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-Fr, IHC-P
MAB14253R
Species: Hu
Applications: B/N

Publications for Epiregulin Antibody (MAB14253R) (0)

There are no publications for Epiregulin Antibody (MAB14253R).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Epiregulin Antibody (MAB14253R) (0)

There are no reviews for Epiregulin Antibody (MAB14253R). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for Epiregulin Antibody (MAB14253R) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional Epiregulin Products

Diseases for Epiregulin Antibody (MAB14253R)

Discover more about diseases related to Epiregulin Antibody (MAB14253R).
 

Pathways for Epiregulin Antibody (MAB14253R)

View related products by pathway.

PTMs for Epiregulin Antibody (MAB14253R)

Learn more about PTMs related to Epiregulin Antibody (MAB14253R).

Blogs on Epiregulin

There are no specific blogs for Epiregulin, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Epiregulin Antibody (870110R) [Unconjugated] and receive a gift card or discount.

Bioinformatics

Uniprot