Endothelin-3 Antibody (3B6) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 3B6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

Endothelin-3 Antibody (3B6) [Janelia Fluor® 549] Summary

• Immunogen: Human Endothelin-3 synthetic peptide
  Accession # P14138
• Specificity: Detects human Endothelin‑3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: EDN3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Endothelin-3 Antibody (3B6) [Janelia Fluor® 549]

• EDN3
• endothelin 3
• Endothelin3
• Endothelin-3
• ET3
• ET-3
• HSCR4
• MGC15067
• MGC61498
• PPET3
• preproendothelin-3
• truncated endothelin 3
• WS4B

Background

Endothelin 3 is encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EDN3