Endothelin-3 Antibody (3B6) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 3B6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Endothelin-3 Antibody (3B6) [Alexa Fluor® 750] Summary

• Immunogen: Human Endothelin-3 synthetic peptide
  Accession # P14138
• Specificity: Detects human Endothelin‑3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Endothelin-3 Antibody (3B6) [Alexa Fluor® 750]

• EDN3
• endothelin 3
• Endothelin3
• Endothelin-3
• ET3
• ET-3
• HSCR4
• MGC15067
• MGC61498
• PPET3
• preproendothelin-3
• truncated endothelin 3
• WS4B

Background

Endothelin-1, -2, and -3 are encoded by three separate genes as prepropolypeptides that are cleaved to yield the secreted and inactive big endothelins. Big
Endothelin-3 is further cleaved by Kell blood group antigen endopeptidases to generate the 21 amino acid (aa) bioactive mature peptide. It interacts primarily with the 7TM receptor EDNRB to induce a variety of effects including bronchoconstriction, arteriolar vasoconstriction, gall bladder contraction, insulin and norepinephrine release, and the maintenance and development of melanocytes and neural crest progenitors. Mature human Endothelin-3 shares 100% aa sequence identity with mouse and rat Endothelin-3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.