Endothelin-1 Quantikine ELISA Kit

• Reactivity: All-Multi
• Applications: ELISA
• Conjugate: HRP

Endothelin-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Endothelin-1 immunoassay is a 4.5 hour solid phase ELISA designed to measure ET-1 in cell culture supernates, serum, plasma, and urine. It contains synthetic ET-1 and antibodies raised against synthetic ET-1. This immunoassay has been shown to accurately quantitate synthetic and naturally occurring ET-1.
• Specificity: Synthetic and natural Endothelin-1
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Endothelin-1 Quantikine ELISA Kit

• ARCND3
• EDN1
• endothelin 1
• Endothelin-1
• ET1
• HDLCQ7
• PPET1
• preproendothelin-1
• QME

Background

Endothelin-1 (ET-1), a peptide of 21 amino acid (aa) residues, is a pleiotropic molecule best known for its action as a potent vasoconstrictor (1). Originally isolated from porcine aortic endothelial cells, ET-1 is one of a family of three proteins encoded by distinct genes that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3) (2, 3). ET-2 and ET-3 differ from ET-1 by 2 and 6 amino acids, respectively (1, 2). All members of the Endothelin family contain two essential disulfide bridges and six conserved aa residues at the C-terminus. Human ET-1 is initially synthesized as a pre-pro-polypeptide of 212 amino acids (2, 4). It is proteolytically cleaved by a signal peptidase to produce pro-ET-1 and further processed by a Furin-like protease to yield a 38 aa peptide termed Big ET-1 (5, 6). Big ET-1 is then cleaved by the membrane-bound metalloprotease Endothelin-converting enzyme (ECE-1), producing the potent 21 aa mature form ET-1 (aa 1-21) (7, 8). Alternatively, ET-1 may exist in an active 31 aa form (ET-1 (aa 1-31)) following cleavage of Big ET-1 by chymase (9-12). The vascular endothelium is an abundant source of ET-1 (3, 13). It may also be expressed by leukocytes, smooth muscle cells, mesangial cells, cardiac myocytes, and astrocytes (14, 15). ET-1 can be induced in endothelial cells by many factors including mechanical stimulation, various hormones, and pro-inflammatory cytokines (16). Production is inhibited by nitric oxide (NO), Prostacyclin, and atrial natriuretic peptide (ANP) (17-19). 

Two receptors for the Endothelin family have been cloned and designated ETA and ETB (20-23). ETA and ETB belong to the large family of heptahelical G protein-coupled receptors. The ETA receptor shows a higher affinity for ET-1 than for ET-2 and lowest affinity for ET-3, while the ETB receptor shows approximately equal affinity for each of the three Endothelins (21, 22, 24). ETA is primarily responsible for the vasoconstrictor effects of ET-1 and is expressed by blood vessel smooth muscle cells (25, 26). The ETB receptor is also present in smooth muscle and the endothelia of blood vessels, kidney, lung, and brain (27). ET-1 has the ability to activate an array of signaling cascades including classical phosphatidylinositol turnover pathways leading to downstream PKC activation and Ca²⁺ mobilization (28-32). Other potential signaling mediators activated or produced by ET-1 include PI 3-kinase/Akt, NO, FAK, and Rho GTPases (32-37). ET-1 signaling may also be mediated indirectly via transactivation of the EGF receptor leading to downstream signaling by Ras and MAP kinases (38, 39). Injection of a single dose of ET-1 produces an initial decrease in systemic blood pressure followed by a prolonged increase in blood pressure (16, 40, 41). Blockade of Endothelin receptors with a systemic injection of an ETA/ETB antagonist causes progressive vasodilation, and elevated levels of ET-1 are found in some forms of human hypertension (42, 43). ET-1 also stimulates cardiac contraction and the growth of cardiac myocytes, regulates the release of vasoactive substances, and stimulates smooth muscle cell mitogenesis (32, 44-46). It also acts as a pro-survival factor for endothelial cells and regulates secretion by hypothalamic and pituitary cells (47, 48). ET-1 may control inflammatory responses by promoting the adhesion and migration of neutrophils and stimulating the production of pro-inflammatory cytokines (49-53). It has also been implicated in cancer progression at several levels including regulating the proliferation and migration of tumor cells and acting as a pro-angiogenic factor (54, 55). In addition, ET-1 has putative roles in other pathologies including septic shock, atherosclerosis, heart failure, renal insufficiency, pulmonary hypertension, and cerebrovascular conditions associated with subarachnoid hemorrhage (15, 56-63).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Endothelin-1 (DET100)(89)

Publications using DET100

• Feriel, B;Alessandra, C;Deborah, GJ;Corinne, N;Raphaël, T;Mina, O;Ali, A;Jean-Baptiste, M;Guillaume, F;Julien, G;Maria-Rosa, G;Elie, F;Laurent, S;Olaf, M;Ly, T;Marc, H;Christophe, G; Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy Scientific reports 2024-11-16 [PMID: 39550495] (Human, Porcine)
• Sun, Y;Kronenberg, NM;Sethi, SK;Dash, SN;Kovalik, ME;Sempowski, B;Strickland, S;Raina, R;John Sperati, C;Tian, X;Ishibe, S;Hall, G;Gather, MC; CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes bioRxiv : the preprint server for biology 2024-10-26 [PMID: 39484460] (Human)
• Zhu, MM;Dai, J;Dai, Z;Peng, Y;Zhao, YY; GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension JCI insight 2024-09-24 [PMID: 39316438] (Human)
• Mayyas, F;Ibrahim, K;Ibdah, R;Al-Kasasbeh, A;Ababneh, MJ;Ababneh, AA;Jarrah, MI;Rawashdeh, S; Association of plasma endothelin-1 levels with revascularization strategies and short-term clinical outcomes: Role of diabetes Heliyon 2024-09-30 [PMID: 39315138] (Human)
• Anfray, A;Schaeffer, S;Hattori, Y;Santisteban, MM;Casey, N;Wang, G;Strickland, M;Zhou, P;Holtzman, DM;Anrather, J;Park, L;Iadecola, C; A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury Nature neuroscience 2024-09-18 [PMID: 39294490] (Human)
• Totaro, P;Tirelli, C;De Amici, M;Grosjean, F;Testa, G;Sacchi, L;De Silvestri, A;Alloni, A;Kushta, E;Albertini, R;Rampino, T;D'Armini, AM; Circulating Endothelin 1 but Not Transforming Growth Factor-? Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study Journal of clinical medicine 2024-08-23 [PMID: 39274190] (Human)
• Gonsalves, AM;Baker, SE;Jacob, DW;Harper, JL;Manrique-Acevedo, CM;Limberg, JK; Effect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men Physiological reports 2024-09-01 [PMID: 39218615] (Human)
• Ho?da, MK;Ra?ny, U;Sordyl, M;Góralska, J;Kapusta, M;S?owi?ska-Solnica, K;Wojtysiak, D;Lis, G;Solnica, B;Kope?, G;Ho?da, J; Autophagy and ubiquitin-dependent proteolysis processes in left ventricular mass loss in pulmonary arterial hypertension Scientific reports 2024-07-02 [PMID: 38956194] (Rat)
• Ren, J;Ren, B;Fu, T;Ma, Y;Tan, Y;Zhang, S;Li, Y;Wang, Q;Chang, X;Tong, Y; Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis International journal of medical sciences 2024-04-08 [PMID: 38774750] (Mouse)
• Domingo, JC;Battistini, F;Cordobilla, B;Zaragozá, MC;Sanmartin-Sentañes, R;Alegre-Martin, J;Cambras, T;Castro-Marrero, J; Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study Journal of translational medicine 2024-04-10 [PMID: 38600563] (Human)
• Vega-Jasso, AL;Amezcua-Guerra, LM;González-Pacheco, H;Sandoval-Zárate, J;González-Díaz, CA;Escobar-Alvarado, J;Manzano-Luna, JD;Brianza-Padilla, M; Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis International journal of molecular sciences 2023-09-28 [PMID: 37834123] (Human)
• Ponasenko, A;Sinitskaya, A;Sinitsky, M;Khutornaya, M;Barbarash, O; The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease Biomedicines 2023-08-25 [PMID: 37760823] (Human)
• Pulito-Cueto, V;Remuzgo-Martínez, S;Genre, F;Atienza-Mateo, B;Mora-Cuesta, VM;Iturbe-Fernández, D;Lera-Gómez, L;Mora-Gil, MS;Portilla, V;Corrales, A;Blanco, R;Cifrián, JM;González-Gay, MA;López-Mejías, R; E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases International journal of molecular sciences 2023-08-07 [PMID: 37569893] (Human)
• T Cambras, MF Zerón-Ruge, A Díez-Nogue, MC Zaragozá, JC Domingo, R Sanmartin-, J Alegre-Mar, J Castro-Mar Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation International Journal of Molecular Sciences, 2023-03-02;24(5):. 2023-03-02 [PMID: 36902264] (Human)
• V Pulito-Cue, F Genre, R López-Mejí, VM Mora-Cuest, D Iturbe-Fer, V Portilla, M Sebastián, JG Ocejo-Viny, O Gualillo, R Blanco, A Corrales, I Ferraz-Ama, S Castañeda, JM Cifrián Ma, B Atienza-Ma, S Remuzgo-Ma, MÁ González-G Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases International Journal of Molecular Sciences, 2023-01-09;24(2):. 2023-01-09 [PMID: 36674789] (Human)
• P Tocci, C Roman, R Sestito, V Di Castro, A Sacconi, I Molineris, F Paolini, M Carosi, G Tonon, G Blandino, A Bagnato Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition Cell Death & Disease, 2023-01-05;14(1):5. 2023-01-05 [PMID: 36604418] (Human)
• NG Gumanova, NL Bogdanova, VA Metelskaya, VI Tarasov, AY Kots, VA Kutsenko, AV Kontsevaya, OM Drapkina Serum biomarkers, including nitric oxide metabolites (NOx), for prognosis of cardiovascular death and acute myocardial infarction in an ESSE-RF case-control cohort with 6.5-year follow up Scientific Reports, 2022-10-28;12(1):18177. 2022-10-28 [PMID: 36307429] (Human)
• A Weigert, X Zheng, A Nenzel, K Turkowski, S Günther, E Strack, E Sirait-Fis, E Elwakeel, IM Kur, VS Nikam, C Valasaraja, H Winter, A Wissgott, R Voswinkel, F Grimminger, B Brüne, W Seeger, SS Pullamsett, R Savai Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Nature Communications, 2022-10-14;13(1):6078. 2022-10-14 [PMID: 36241617] (Human)
• BR Fato, N de Alwis, S Beard, NK Binder, N Pritchard, S Tong, TJ Kaitu'u-Li, NJ Hannan Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries-A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142764] (Human)
• E Tudorache, O Fira-Mladi, D Traila, M Marc, RM Rajnoveanu, DE Tofolean, AP Fildan Endothelial dysfunction: The possible link between cardiovascular comorbidities and phenomenon of inflammaging from COPD Medicine, 2022-08-19;101(33):e30078. 2022-08-19 [PMID: 35984178] (Human)
• NP Rocha, O Charron, GD Colpo, LB Latham, JE Patino, EF Stimming, L Freeman, AL Teixeira Cerebral blood flow is associated with markers of neurodegeneration in Huntington's disease Parkinsonism & related disorders, 2022-08-06;102(0):79-85. 2022-08-06 [PMID: 35973322] (Human)
• N de Alwis, NK Binder, YTM Mangwiro, S Beard, N Pritchard, E Kadife, BR Fato, E Keenan, FC Brownfoot, TJ Kaitu'u-Li, NJ Hannan Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia International Journal of Molecular Sciences, 2022-07-25;23(15):. 2022-07-25 [PMID: 35897759] (Mouse)
• A Orea-Tejad, C Sánchez-Mo, OG Aztatzi-Ag, MP Sierra-Var, D González-I, Y Debray-Gar, MS Ortega-Rom, C Keirns-Dav, L Cornejo-Co, J Aguilar-Me Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients Journal of Clinical Medicine, 2022-07-07;11(14):. 2022-07-07 [PMID: 35887714] (Human)
• C Lommatzsch, K Rothaus, L Schopmeyer, M Feldmann, D Bauer, S Grisanti, C Heinz, M Kasper Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma Scientific Reports, 2022-07-12;12(1):11801. 2022-07-12 [PMID: 35821224] (Human)
• J Baran, ? Niewiara, J Podolec, M Siedli?ski, E Józefczuk, A Bernacik, R Badacz, T Przew?ocki, P Pieni??ek, K ?mudka, J Legutko, A Kab?ak-Zie Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes Oncogene, 2022-06-17;9(6):. 2022-06-17 [PMID: 35735822] (Human)
• S Macdonald, E Bosio, NI Shapiro, L Balmer, S Burrows, M Hibbs, T Jowitt, L Smart, G Arendts, D Fatovich No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department Scientific Reports, 2022-05-24;12(1):8733. 2022-05-24 [PMID: 35610344] (Human)
• HM Kang, M Hasanuzzam, SW Kim, HJ Koh, SC Lee Elevated aqueous endothelin-1 concentrations in advanced diabetic retinopathy PLoS ONE, 2022-05-11;17(5):e0268353. 2022-05-11 [PMID: 35544533] (Human)
• X Yang, R Dai, Z Qin, R Cai, Y Xu, Q Su LncRNA MALAT1 functions as a biomarker of no-reflow phenomenon in ST-segment elevation myocardial infarction patients receiving primary percutaneous coronary intervention Scientific Reports, 2022-02-28;12(1):3294. 2022-02-28 [PMID: 35228564] (Human)
• V Montiel, I Lobysheva, L Gérard, M Vermeersch, D Perez-Morg, T Castelein, JB Mesland, P Hantson, C Collienne, D Gruson, MA van Dievoe, A Persu, C Beauloye, M Dechamps, L Belkhir, A Robert, M Derive, PF Laterre, AHJ Danser, X Wittebole, JL Balligand Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients EBioMedicine, 2022-02-23;77(0):103893. 2022-02-23 [PMID: 35219085] (Human)
• CT Vong, Y Chen, Z Chen, C Gao, F Yang, S Wang, Y Wang Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis Journal of ethnopharmacology, 2022-01-13;0(0):114992. 2022-01-13 [PMID: 35032586] (Mouse)
• X Nie, C Shen, J Tan, X Yang, W Wang, Y Dai, H Sun, Z Wu, J Chen Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling Biomolecules, 2021-11-30;11(12):. 2021-11-30 [PMID: 34944445] (Human)
• M Velásquez, LF Peláez, M Rojas, R Narváez-Sá, JA Velásquez, C Escudero, S San Martín, ÁP Cadavid Differences in Endothelial Activation and Dysfunction Induced by Antiphospholipid Antibodies Among Groups of Patients With Thrombotic, Refractory, and Non-refractory Antiphospholipid Syndrome Frontiers in Physiology, 2021-12-02;12(0):764702. 2021-12-02 [PMID: 34925061] (Human)
• I Dakota, M Munawar, R Pranata, WM Raffaello, R Sukmawan Diagnostic prediction model in subjects with low-risk unstable angina pectoris/non-ST segment Elevation Myocardial Infarction European review for medical and pharmacological sciences, 2021-08-01;25(16):5145-5152. 2021-08-01 [PMID: 34486689] (Human)
• S Ríos-Arrab, JD Puentes-Pa, S Moreno-San, Á Szuba, J Casado, M García-Cos, J Escudero-F, M Verbeni, C Cano, C González-P, A Martín-Lag, Á Carazo, J León Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53 Journal of personalized medicine, 2021-06-04;11(6):. 2021-06-04 [PMID: 34199777] (Human)
• HM Kang, M Hasanuzzam, SW Kim, HJ Koh, SC Lee Significant elevation of aqueous endothelin-1 in central retinal vein occlusion PLoS ONE, 2021-06-02;16(6):e0252530. 2021-06-02 [PMID: 34077461] (Human)
• E Nassar, N Hassan, EA El-Ghonaim, H Hassan, MS Abdullah, TV Rottke, L Kiesel, B Greve, SA Ibrahim, M Götte Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes Cancers, 2021-05-12;13(10):. 2021-05-12 [PMID: 34066023] (Human)
• T Kato, T Nakajima, T Fukuda, I Shibasaki, T Hasegawa, K Ogata, H Ogawa, S Hirota, H Ohashi, S Saito, Y Takei, M Tezuka, M Seki, T Kuwata, M Sakuma, S Abe, S Toyoda, T Inoue, H Fukuda Preoperative Serum GDF-15, Endothelin-1 Levels, and Intraoperative Factors as Short-Term Operative Risks for Patients Undergoing Cardiovascular Surgery Journal of Clinical Medicine, 2021-05-02;10(9):. 2021-05-02 [PMID: 34063283] (Human)
• GA Payne, NS Sharma, CV Lal, C Song, L Guo, C Margaroli, L Viera, S Kumar, J Li, M Bosley, D Xing, X Xu, JM Wells, JF George, JA Tallaj, M Leesar, JE Blalock, A Gaggar Prolyl Endopeptidase contributes to early neutrophilic inflammation in acute cardiac transplant rejection JCI Insight, 2021-03-22;0(0):. 2021-03-22 [PMID: 33571164] (Mouse)
• Y Osawa, S Yoshio, Y Aoki, M Korenaga, M Imamura, T Oide, M Okawara, H Kawai, Y Tsutsui, Y Yoshida, S Yoshikawa, T Mori, T Yamazoe, T Kanto Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients BMC gastroenterology, 2021-02-08;21(1):55. 2021-02-08 [PMID: 33557759] (Human)
• CVB Figueiredo, RP Santiago, CC da Guarda, RM Oliveira, LM Fiuza, SCMA Yahouédého, SP Carvalho, JSDS Neres, AMJ Oliveira, CA Fonseca, VML Nascimento, IM Lyra, MM Aleluia, MS Goncalves Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers PLoS ONE, 2021-02-04;16(2):e0246067. 2021-02-04 [PMID: 33539452] (Human)
• Q Yu, K Li, A Zhao, M Wei, Z Huang, Y Zhang, Y Chen, L Ting, W Chuan, L Xu, Y Zhang, C Xu, F Liu Sorafenib not only impairs endothelium-dependent relaxation but also promotes vasoconstriction through the upregulation of vasoconstrictive endothelin type B receptors Toxicology and Applied Pharmacology, 2021-01-24;414(0):115420. 2021-01-24 [PMID: 33503445] (Rat)
• JC Monroe, Q Song, MS Emery, DM Hirai, RL Motaganaha, BT Roseguini Acute effects of leg heat therapy on walking performance and cardiovascular and inflammatory responses to exercise in patients with peripheral artery disease Physiological Reports, 2021-01-01;8(24):e14650. 2021-01-01 [PMID: 33369253] (Human)
• RP Santiago, CVB Figueiredo, LM Fiuza, SCMA Yahouédého, RM Oliveira, MM Aleluia, SP Carvalho, CA Fonseca, VML Nascimento, LC Rocha, CC Guarda, MS Gonçalves TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia Dis Markers, 2020-09-30;2020(0):8867986. 2020-09-30 [PMID: 33062074] (Human)
• A Schiappaca, PA Maranhão, MDGC Souza, DG Panazzolo, JF Nogueira N, E Bouskela, LG Kraemer-Ag Acute Effects of Metformin and Vildagliptin after a Lipid-Rich Meal on Postprandial Microvascular Reactivity in Patients with Type 2 Diabetes and Obesity: A Randomized Trial J Clin Med, 2020-10-09;9(10):. 2020-10-09 [PMID: 33050169] (Human)
• J Chen, J Argemi, G Odena, MJ Xu, Y Cai, V Massey, A Parrish, R Vadigepall, J Altamirano, J Cabezas, P Gines, J Caballeria, N Snider, P Sancho-Bru, S Akira, I Rusyn, B Gao, R Bataller Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension Scientific Reports, 2020-09-23;10(1):15558. 2020-09-23 [PMID: 32968110] (Human)
• ZH Maayah, S Takahara, AS Alam, M Ferdaoussi, G Sutendra, AOS El-Kadi, JR Mackey, E Pituskin, DI Paterson, JRB Dyck Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling BMC Cancer, 2020-08-12;20(1):751. 2020-08-12 [PMID: 32787791] (Human)
• Z Piotrowicz, M Chalimoniu, K P?oszczyca, M Czuba, J Langfort Exercise-Induced Elevated BDNF Level Does Not Prevent Cognitive Impairment Due to Acute Exposure to Moderate Hypoxia in Well-Trained Athletes Int J Mol Sci, 2020-08-04;21(15):. 2020-08-04 [PMID: 32759658] (Human)
• MR Kim, HJ Kim, SH Yu, BS Lee, SY Jeon, JJ Lee, YC Lee Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model Evid Based Complement Alternat Med, 2020-05-23;2020(0):7941391. 2020-05-23 [PMID: 32595737] (Rat)
• JM Jung, TK Noh, SY Jo, SY Kim, Y Song, YH Kim, SE Chang Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation Molecules, 2020-06-05;25(11):. 2020-06-05 [PMID: 32517074] (Human)
• DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy PLoS ONE, 2020-04-27;15(4):e0232287. 2020-04-27 [PMID: 32339208] (Human)
• V Selvaraju, P Ayine, M Fadamiro, JR Babu, M Brown, T Geetha Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction Oxid Med Cell Longev, 2019-10-16;2019(0):9604740. 2019-10-16 [PMID: 31737180] (Human)
• M Castellazz, G Lamberti, MV Resi, E Baldi, LM Caniatti, G Galante, P Perri, M Pugliatti Increased Levels of Endothelin-1 in Cerebrospinal Fluid Are a Marker of Poor Visual Recovery after Optic Neuritis in Multiple Sclerosis Patients Dis. Markers, 2019-09-10;2019(0):9320791. 2019-09-10 [PMID: 31583031] (Human)
• A Niewiarows, A Kozik, I Guevara-Lo Influence of bradykinin B2 receptor and dopamine D2 receptor on the oxidative stress, inflammatory response, and apoptotic process in human endothelial cells PLoS ONE, 2018-11-14;13(11):e0206443. 2018-11-14 [PMID: 30427893] (Human)
• CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018-11-08;7(11):. 2018-11-08 [PMID: 30413105] (Human)
• Y Kong, Y Gao, D Lan, Y Zhang, R Zhan, M Liu, Z Zhu, G Zeng, Q Huang Trans-repression of NF?B pathway mediated by PPAR? improves vascular endothelium insulin resistance J. Cell. Mol. Med., 2018-11-05;0(0):. 2018-11-05 [PMID: 30398029] (Rat)
• N Chebib, F Archer, A Bobet-Erny, C Leroux, V Cottin Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration Sci Rep, 2018-10-02;8(1):14698. 2018-10-02 [PMID: 30279475] (Human)
• M Houde, A Schwertani, H Touil, L Desbiens, O Sarrhini, R Lecomte, M Lepage, H Gagnon, S Takai, G Pejler, D Jacques, F Gobeil, R Day, P D'Orléans- Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction Front Pharmacol, 2018-08-31;9(0):868. 2018-08-31 [PMID: 30233357] (Mouse)
• I Roato, DC Belisario, M Compagno, L Verderio, A Sighinolfi, F Mussano, T Genova, F Veneziano, G Pertici, G Perale, R Ferracini Adipose-Derived Stromal Vascular Fraction/Xenohybrid Bone Scaffold: An Alternative Source for Bone Regeneration Stem Cells Int, 2018-04-29;2018(0):4126379. 2018-04-29 [PMID: 29853912] (Human)
• YH Li, WH Sheu, WJ Lee, J- Wang, CP Fu, KW Liang, IT Lee Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ? a cross-sectional study Sci Rep, 2018-05-09;8(1):7378. 2018-05-09 [PMID: 29743680] (Human)
• M Caldeira-D, MR Luizon, E Deffune, JE Tanus-Sant, PP Freire, RF Carvalho, H Bettiol, VC Cardoso, M Antonio Ba, RC Cavalli, VC Sandrim Preeclamptic plasma stimulates the expression of miRNAs, leading to a decrease in endothelin-1 production in endothelial cells Pregnancy Hypertens, 2018-03-27;12(0):75-81. 2018-03-27 [PMID: 29674204] (Human)
• F Mayyas, R Jaradat, KH Alzoubi Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes Nutr Metab Cardiovasc Dis, 2018-02-25;0(0):. 2018-02-25 [PMID: 29615288] (Rat)
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