Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (SPM255) - IHC-Prediluted

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Product Details

Summary
Reactivity Hu, Mu, Po, Fi, Mk, PmSpecies Glossary
Applications IHC-P
Clone
SPM255
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Format
IHC-Prediluted

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Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (SPM255) - IHC-Prediluted Summary

Immunogen
Murine EHS laminin preparation
Localization
Basement membrane
Specificity
This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
HSPG2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Hu-chromosome location: 1p36.1-p34 Molecular weight of antigen: >400kDa Immunohistochemistry-Paraffin 1 - 2 ug/ml for 30 minutes at RT; Staining of formalin/paraffin tissues Requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at RT for 20 minutes.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (SPM255) - IHC-Prediluted

  • basement membrane-specific heparan sulfate proteoglycan core protein
  • endorepellin (domain V region)
  • Endorepellin
  • heparan sulfate proteoglycan 2
  • HSPG
  • HSPG2
  • perlecan proteoglycan
  • Perlecan
  • PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
  • PRCAN
  • SJA
  • SJS
  • SJS1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics Tool for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (NBP2-48244)

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Bioinformatics

Gene Symbol HSPG2
Entrez