DYRK3 Antibody (563518) [Alexa Fluor® 405]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 563518
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

DYRK3 Antibody (563518) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human DYRK3
  Asn52-Glu167
  Accession # O43781
• Specificity: Detects human, mouse, and rat DYRK3 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DYRK3 Antibody (563518) [Alexa Fluor® 405]

• dual specificity tyrosine-phosphorylation-regulated kinase 3
• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
• DYRK3
• DYRK5
• EC 2.7.12
• EC 2.7.12.1
• hYAK3-2
• protein kinase Dyrk3
• REDK
• REDKRED
• Regulatory erythroid kinase
• YAK3-2

Background

DYRK3 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 3; also REDK) is a 70‑72 kDa member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. It is expressed in testis and erythroid-lineage precursors, and shows dual substrate specificity; autophosphorylation on Tyr369 to self‑activate, and a Ser/Thr phosphorylation of target molecules. Substrates include CREB and Histone 2B. Human DYRK3 is 588 amino acids (aa) in length and contains one kinase catalytic domain (aa 209‑522). There are two potential isoform variants that show either a six aa substitution for aa 1‑26, or this same substitution in combination with a premature truncation after Gln263. DYRK3 immunoreactive proteolysis bands of 30 and 40 kDa have been detected in DYRK3-transfected cells. Over aa 52‑167, human DYRK3 shares 75% aa identity with mouse DYRK3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.