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DYRK3, or dual specificity tyrosine-phosphorylation-regulated kinase 3, is a negative regulator of EPO-dependent erythropoiesis and may place an upper limit on red cell production during stress erythropoiesis. DYRK3 inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells, and may also act by regulating CREB/CRE signaling.