DR3/TNFRSF25 Antibody

Product Discontinued

DR3/TNFRSF25 Antibody Summary

• Immunogen: Rabbit anti-DR3 (ED) polyclonal antibody was raised against a peptide corresponding to amino acids 59 to 77 in extracellular domain (ED) of human DR3 precusor1,2.
• Specificity: DR3 / Wsl-1/ Apo-3
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFRSF25
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: This polyclonal antibody can be used for detection of DR3 expression by Western blot at 1:500 to 1:1000 dilution. Jurkat total cell lysate can be used as positive control and a 59 kDa band should be detected. It is human and mouse reactive.

Reactivity Notes

Human, Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: IgG purified

Alternate Names for DR3/TNFRSF25 Antibody

• APO3
• Apo-3
• Apoptosis-inducing receptor AIR
• Apoptosis-mediating receptor DR3
• Apoptosis-mediating receptor TRAMP
• Death receptor 3
• DR3
• DR3member 12 (translocatingchain-association membrane protein)
• LARD
• Lymphocyte-associated receptor of death
• Protein WSL
• Protein WSL-1
• TNFRSF25
• TRAMP
• tumor necrosis factor receptor superfamily, member 25
• WSL
• WSL1
• WSL-1

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF25
• Entrez:
  • 8718(Human)
• Uniprot:
  • Q93038()