DR3/TNFRSF25 Antibody (JD3) [DyLight 650]

• Reactivity: Hu
• Applications: Flow
• Clone: JD3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

DR3/TNFRSF25 Antibody (JD3) [DyLight 650] Summary

• Immunogen: human DR3/TNFRSF25-Ig fusion protein
• Specificity: The mouse monoclonal antibody JD3 recognizes an extracellular epitope of DR3 (APO-3, TNFRSF25), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNFRSF25
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DR3/TNFRSF25 Antibody (JD3) [DyLight 650]

• APO3
• Apo-3
• Apoptosis-inducing receptor AIR
• Apoptosis-mediating receptor DR3
• Apoptosis-mediating receptor TRAMP
• Death receptor 3
• DR3
• DR3member 12 (translocatingchain-association membrane protein)
• LARD
• Lymphocyte-associated receptor of death
• Protein WSL
• Protein WSL-1
• TNFRSF25
• TRAMP
• tumor necrosis factor receptor superfamily, member 25
• WSL
• WSL1
• WSL-1

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family, through their death domain containing receptors TNFR1 and Fas. A cell surface receptor with a death domain, DR3, has been identified by several groups independently, although it has been given alternative names. The ligand for DR3 has very recently been identified as TWEAK, also termed Apo3L. DR3 is highly expressed in tissues enriched in lymphocytes including PBL, thymus and spleen. DR3 mediates activation of NF kappa B, and induces apoptosis. DR3 may also play a role in regulating lymphocyte homeostasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF25