DPP6 Antibody - BSA Free

Western Blot: DPP6 Antibody [NBP3-13212] - Various tissue extracts (50 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with DPP6 antibody (NBP3-13212) diluted at 1:1000.

Immunohistochemistry-Frozen: DPP6 Antibody [NBP3-13212] - DPP6 antibody detects DPP6 protein expression by immunohistochemical analysis. Sample: Frozen-sectioned adult mouse hippocampus. Green: DPP6 protein stained by DPP6 antibody (NBP3-13212) diluted at 1:250. Blue: Fluoroshield with DAPI.

Immunohistochemistry-Paraffin: DPP6 Antibody [NBP3-13212] - DPP6 antibody detects DPP6 protein at cell membrane in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. DPP6 antibody (NBP3-13212) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

• Reactivity: Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

DPP6 Antibody - BSA Free Summary

• Description: Centrifuge briefly prior to opening.
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse DPP6. The exact sequence is proprietary.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DPP6
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, 20% Glycerol
• Preservative: 0.025% Proclin 300
• Purity: Antigen Affinity-purified

Alternate Names for DPP6 Antibody - BSA Free

• dipeptidyl aminopeptidase IV-related protein
• dipeptidyl aminopeptidase-like protein 6
• Dipeptidyl aminopeptidase-related protein
• Dipeptidyl peptidase 6
• Dipeptidyl peptidase IV-like protein
• dipeptidyl peptidase IV-related protein
• Dipeptidyl peptidase VI
• dipeptidylpeptidase 6
• dipeptidyl-peptidase 6
• dipeptidylpeptidase VI
• DPP VI
• DPP6
• DPPX
• DPPXFLJ55680
• MGC46605
• VF2

Background

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DPP6