Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, Flow, IHC, IP
Host: Goat Polyclonal
Flow, IP, CyTOF-readyHost:
The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
|Product By Gene ID
- DPP VI
- dipeptidyl peptidase IV-related protein
- Dipeptidyl peptidase VI
- dipeptidyl aminopeptidase-like protein 6
- Dipeptidyl peptidase IV-like protein
- dipeptidyl aminopeptidase IV-related protein
- Dipeptidyl peptidase 6
- Dipeptidyl aminopeptidase-related protein
- dipeptidylpeptidase VI
- dipeptidylpeptidase 6
- dipeptidyl-peptidase 6
Bioinformatics Tool for DPP6
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|The role of DNMT3A in development
Epigenetics is the study of heritable change in gene activity despite alteration of the hosts DNA sequence. Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation. Gene silencing in DNA ... Read more.