VABP Antibody

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Western Blot: VABP Antibody [NBP2-19020] - Analysis of VABP in (A) human brain and (B) human heart cell lysateusing this antibody at 1 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Concentration
0.5 mg/ml

Order Details

VABP Antibody Summary

Immunogen
Within the range of amino acids 1-35 (LQTKQRRPSKDKIEDELE) of human ABP protein were used as the immunogen (NP_055407).
Specificity
The Uniprot number for VABP is Q9NZI2. The amino acid sequence used as immunogen has 100% identity in human, mouse, rat, pig and bovine.
Clonality
Polyclonal
Host
Rabbit
Gene
KCNIP1
Purity
Protein G purified
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Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Reactivity Notes

Reacts with Human, mouse, rat, porcine and bovine.

Alternate Names for VABP Antibody

  • A-type potassium channel modulatory protein 1
  • KChIP1
  • KCHIP1MGC95
  • Kv channel interacting protein 1
  • Kv channel-interacting protein 1
  • potassium channel interacting protein 1
  • Potassium channel-interacting protein 1
  • VABP
  • Vesicle APC-binding protein

Background

The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol KCNIP1
Entrez
Uniprot

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