Dopamine D2R/DRD2 Antibody (960710) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IHC
• Clone: 960710
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Dopamine D2R/DRD2 Antibody (960710) [Alexa Fluor® 350] Summary

• Immunogen: Human DRD2 synthetic peptide
  Accession # P14416
• Specificity: Detects human Dopamine D2 R/DRD2 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Dopamine D2R/DRD2 Antibody (960710) [Alexa Fluor® 350]

• D(2) dopamine receptor
• D2DR
• D2R
• Dopamine D2 R
• Dopamine D2 receptor
• Dopamine D2R
• dopamine receptor D2 isoform
• dopamine receptor D2
• DRD2
• seven transmembrane helix receptor

Background

Dopamine receptor D2 (DRD2) is localized to human striatum, motor cortex and neocortex. It is a highly conserved seven transmembrane receptor member of the G-protein coupled receptor 1 family, with three known isoforms. In the striatum, DRD2 suppresses voluntary activity in the striatopallidal pathway, and polymorphisms in this gene are associated with alcohol addiction, smoking behavior, schizophrenia, food addiction and post-traumatic stress disorder as well as myoclonus dystonia.  DRD2 has been shown to heterodimerize with DDR4 and 5-HT2A receptors, and traffics between the plasma membrane and intracellular pools and this localization can be modulated by several drugs.  DRD2 is localized to human striatum, motor cortex and neocortex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.